Dentoclude™ F  is a bioactive glass comprising SiO2, Na2O, CaO, P2O5, Fluoride, Neem and Dadima. Once in contact with the body fluids, Bioactive glasses immediately undergo ionic dissolution and bioactive glass degradation via the exchange of H+ ions in the solution and Na+ and Ca2+ from the glass network. The ion exchange results in the formation of silanol groups (Si–O–H) due to the hydrolysis of the silica groups. An increased alkaline local environment develops due to the increase in OH- concentration. The silica network is further degraded as the pH rises, forming orthosilicic acid and Si (OH)4 on the surface in the form of a negatively charged gel. The gel layer functions as a matrix for hydroxyapatite with precipitation sites. Beneath the gel layer is a depleted alkaline surface layer on top of the bulk glass. On top of the gel layer, a layer of amorphous calcium phosphate forms. Precipitation and further mineralization occur due to the incorporated carbonate ions from the now supersaturated solution, thus the concentration of Ca- and Si-ions in solution are critical. The newly formed hydroxyapatite enables growth factors to adsorb to the surface, as well as attachment, proliferation, and differentiation of osteoprogenitor cells by cytokines and extracellular matrix components expressed by the upregulation of several genes. Collagen and glycoproteins are believed to incorporate the surrounding bone tissue into the hydroxyapatite layer. As the hydroxyapatite grows inwards, the Bioactive glass starts to resorb and gets replaced by growing bone tissue. Osteoclasts, once incorporated in the growing bone, break down larger particles resulting in a more extended period of resorption and stronger bone.